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CCT244747 Chemical Structure

CCT244747

Data Sheet For research use only. Not for human use.
Cat. No. :BCP23872CAS No. :1404095-34-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1404095-34-6 Cat. No. BCP23872
Name CCT244747
Synonyms CCT-244747; CCT 244747;
SMILES CC(CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C(C(=C2)OC)C3=CN(N=C3)C
Chemical Name
Formula C20H24N8O2 M. Wt 408.46
Purity 98% Storage Store at 4-8°C
Description CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies.
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