CCT245737 Hot
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1489389-18-5 | Cat. No. | BCP18991 |
| Name | CCT245737 | ||
| Synonyms | CCT-245737;CCT 245737; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H16F3N7O | M. Wt | 379.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | In vitro: CCT245737 shows <50% inhibition at 10 μM for 85/121 kinases, representing a selectivity for CHK1 inhibition of >5000-fold over these enzymes. [1] CCT245737 enhanced gemcitabine antitumor activity to a greater degree than for higher doses of either agent alone, without increasing toxicity. In vivo: CCT2457374 shows an increase in plasma and tumoconcentrations between 3?100 mg/kg po. | ||
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