Quisinostat HCl New
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| CAS No. | 1083078-98-1 | Cat. No. | BCP44306 |
| Name | Quisinostat HCl | ||
| Synonyms | Quisinostat hydrochloride;JNJ26481585; JNJ-26481585; JNJ 26481585; | ||
| SMILES | CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO.Cl | ||
| Chemical Name | |||
| Formula | C21H27ClN6O2 | M. Wt | 430.94 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation. | ||
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