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CAS No. | 156-54-7 | Cat. No. | BCP31813 |
Name | Sodium Butyrate | ||
Synonyms | Butyric acid sodium salt; | ||
SMILES | CCCC(=O)[O-].[Na+] | ||
Chemical Name | |||
Formula | C4H7NaO2 | M. Wt | 110.09 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling. |
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