KT-531 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP48476CAS No. ：2490284-18-7Purity：98%

Get Quotation Now

Tel: 0086-17754423994 or orders@biochempartner.com

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

* Required Fields.

Please complete the form below and we will contact you shortly.

* Required Fields.

Please complete the form below and we will contact you shortly.

CAS No.	2490284-18-7	Cat. No.	BCP48476
Name	KT-531
Synonyms	KT531;KT 531;
SMILES
Chemical Name
Formula	C17H14F4N2O4S	M. Wt	418.36
Purity	98%	Storage	Store at 4-8°C
Description	KT-531 is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms;KT-531 demonstrated biological potency in multiple hematological cancer cell models (acute myeloid leukemia (AML), PTCL, and T-cell acute lymphoblastic leukemia (T-ALL)) and limited cytotoxicity in nonmalignant cell types as well as no observable toxicity in vivo (CD-1 mice).KT-531 exhibited strong potency (IC50=0.42 μM) in the T-ALL/T-PLL-like cell line SUP-T11, demonstrated higher cytotoxicity than Nexturastat in MV4-11 cancer cells (IC50=0.42 uM versus 1.68 uM).KT-531 showed high synergy with chemotherapeutic agents idasanutlin, bendamustine, and venetoclax in T-PLL patient samples.KT-531 is the first HDAC6 inhibitor to show efficacy in T-PLL patient samples.