GSK1904529A
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1089283-49-7 | Cat. No. | BCP01719 |
| Name | GSK1904529A | ||
| Synonyms | GSK 1904529A;GSK-1904529A;GSK 4529; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C44H47F2N9O5S | M. Wt | 851.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK1904529A is a reversible, ATP-competitive inhibitor and has enzyme-inhibitor binding values against IGF-1R and IR with Ki of 1.6 nM and 1.3 nM, respectively. GSK1904529A potently inhibits the ligand-induced phosphorylation of IGF-1R and IR at concentrations above 0.01 μM, followed by blocking downstream signaling (AKT, IRS-1, and ERK). GSK1904529A potently inhibits NIH-3T3/LISN, TC-71, SK-N-MC, SK-ES RD-ES cells with IC50 of 60 nM, 35 nM, 43 nM, 61 nM and 62 nM, respectively. GSK1904529A also | ||
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