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CAS No. | 475488-23-4 | Cat. No. | BCP27617 |
Name | NVP-ADW742 | ||
Synonyms | ADW; NVP ADW-742; NVP ADW 742; ADW 742; ADW-742; ADW742; GSK 552602A; GSK-552602A; GSK552602A; | ||
SMILES | |||
Chemical Name | |||
Formula | C28H31N5O | M. Wt | 453.58 |
Purity | 98% | Storage | Store at 4-8°C |
Description | NVP-ADW742, also known as ADW-742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells. |
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