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NVP-ADW742 Chemical Structure

NVP-ADW742

Data Sheet For research use only. Not for human use.
Cat. No. :BCP27617CAS No. :475488-23-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 475488-23-4 Cat. No. BCP27617
Name NVP-ADW742
Synonyms ADW; NVP ADW-742; NVP ADW 742; ADW 742; ADW-742; ADW742; GSK 552602A; GSK-552602A; GSK552602A;
SMILES
Chemical Name
Formula C28H31N5O M. Wt 453.58
Purity 98% Storage Store at 4-8°C
Description NVP-ADW742, also known as ADW-742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells.
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