GSK 621659A New
Data Sheet
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| CAS No. | 475489-15-7 | Cat. No. | BCP25985 |
| Name | GSK 621659A | ||
| Synonyms | NVP-ADW742;ADW-742; | ||
| SMILES | C1CCN(C1)CC2CC(C2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=CC=C5)OCC6=CC=CC=C6 | ||
| Chemical Name | |||
| Formula | C28H31N5O | M. Wt | 453.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK 552602A is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells. | ||
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