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Indoximod Chemical Structure

Indoximod

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP08015CAS No. ：110117-83-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 110117-83-4 Cat. No. BCP08015
Name Indoximod
Synonyms NLG-8189;NLG 8189;NLG8189;1-Methyl-D-tryptophan;
SMILES
Chemical Name
Formula C12H14N2O2 M. Wt 218.25
Purity 98% Storage Store at 4-8°C
Description 1-Methyl-D-tryptophan is an inhibitor of the enzymes IDO and INDOL1 (indolamine 2,3-dioxygenase 1 and 2) with selectivity for INDOL1. The enzymes perform similar transformations and are responsible for catalyzing the rate-limiting step of oxidative tryptophan catabolism in the kynurenine pathway. IDO activity is correlated with an induction of tolerance and immunosuppresion through activation of regulatory T cells by metabolites generated from tryptophan catabolism. Inhibition of IDO by 1-Methyl-D-tryptophan blocks this induced immune suppression, which has shown utility in suppressing acquired immunities of tumors and indicates potential for chemical intervention of chronic inflammatory diseases.
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H-NMR HPLC
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