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CAS No. | 1316695-35-8 | Cat. No. | BCP31973 |
Name | LM10 | ||
Synonyms | LM 10; LM-10; | ||
SMILES | C1=CC2=C(C=C1F)NC=C2C=CC3=NNN=N3 | ||
Chemical Name | |||
Formula | C11H8FN5 | M. Wt | 229.22 |
Purity | 98% | Storage | Store at 4-8°C |
Description | LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). LM10 exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. LM10 reduces growth of TDO-expressing P815 mastocytoma tumors in mice. |
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