NLG919

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09887CAS No. ：1402836-58-1Purity：98%

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CAS No.	1402836-58-1	Cat. No.	BCP09887
Name	NLG919
Synonyms	GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078;IDO-IN-7;
SMILES	C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
Chemical Name
Formula	C18H22N2O	M. Wt	282.38
Purity	98%	Storage	Store at 4-8°C
Description	GDC-0919, also known as NLG919 and RG6078, is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon administration, NLG919 targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells.