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PF-06840003 Chemical Structure

PF-06840003

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP17158CAS No. ：198474-05-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 198474-05-4 Cat. No. BCP17158
Name PF-06840003
Synonyms EOS200271; EOS-200271; EOS 200271; PF 06840003; PF06840003;
SMILES O=C(C(C1=CNC2=C1C=C(F)C=C2)C3)NC3=O
Chemical Name
Formula C12H9FN2O2 M. Wt 232.21
Purity 98% Storage Store at 4-8°C
Description PF-06840003, also known as EOS200271, is potent IDO-1 inhibitor (IC50 0.15 μM). PF-0684000 has moderate hIDO1 enzyme inhibition (IC50 0.41 μM). It is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size. PF-0684000 shows good potency in an IDO-1 human whole blood assay and also shows a very favorable ADME profile leading to favorable predicted human pharmacokinetic properties, including a predicted half-life of 16−19 h.
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