Zileuton

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16199CAS No. ：111406-87-2Purity：98%

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CAS No.	111406-87-2	Cat. No.	BCP16199
Name	Zileuton
Synonyms	Zyflo;A 64077;Abbott 64077;Griluto-CR;Leutrol;
SMILES
Chemical Name
Formula	C11H12N2O2S	M. Wt	236.29
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: Zileuton inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic leukemia cell 20,000 x g supernatant and rat polymorphonuclear leukocytes (PMNL) (IC50 = 0.5 and 0.3 microM) respectively. It also inhibited leukotriene (LT)B4 biosynthesis by rat PMNL (IC50 = 0.4 microM), human PMNL (IC50 = 0.4 microM) and human whole blood (IC50 = 0.9 microM) [1]. Zileuton inhibited antigen-induced contractions of guinea-pig tracheal strips (GPTS) from actively sensitized animals with an IC50of 6 microM. in vivo: Additionally, while total tau levels were unchanged for both groups, zileuton-treated mice had a significant reduction in its phosphorylation state and insoluble forms, secondary to a decreased activation of the cdk5 kinase. Neurological deficit scores, infarct volume, and neuronal damage were significantly attenuated by administration of zileuton. MCAO caused the elevation of neuronal apoptosis, which was significantly inhibited by the administration of zileuton. MCAO ca