CV-6504

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP29522CAS No. ：117574-40-0Purity：98%

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Chemical Properties&Biological Activity

CAS No.	117574-40-0	Cat. No.	BCP29522
Name	CV-6504
Synonyms	CV6504;CV 6504;
SMILES	CC1=C(C(=O)C(=C(C1=O)C)CC2=CN=CC=C2)C
Chemical Name
Formula	C15H15NO2	M. Wt	241.29
Purity	98%	Storage	Store at 4-8°C
Description	CV-6504 is an inhibitor of 5-lipoxygenase, effectively suppressed growth of the MAC16 tumour in vivo and prevented the accompanying cachexia, when administered daily at a dose of 10 mg kg(-1).There was a reduction in the tumour concentration of linoleic (LA), arachidonic (AA), oleic, stearic and palmitic acid. In order to elucidate the mechanism of the anti-tumour action, the effect of CV-6504 on the metabolism of AA through the 5-, 12- and 15-lipoxygenase pathways has been determined in cell lines sensitive (MAC16, MAC13, MAC26 and Caco-2) and resistant (A549 and DU-145) to CV-6504. Incubation of all cell lines with [3H]AA led to the appearance of [3H]5-, 12- and 15-HETE. Preincubation of MAC16, MAC13, MAC26 and Caco-2 with 10 microM CV-6504 inhibited the conversion of AA to 5-, 12- and 15-HETE, while in A549 and DU-145 cells there was no effect on metabolism through any lipoxygenase pathway. Two other cell lines, MDA-MB-231 and PC-3, sensitive to growth inhibition by CV-6504, are known to require LA for growth, while DU-145, which was insensitive to growth inhibition by CV-6504, showed no growth response to LA. These results suggest that some tumours are dependent on lipoxygenase metabolites of LA and AA for their continual growth, and interference with this pathway produces a specific growth inhibition.