PXS5505 HCl New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP39659CAS No. ：2409964-23-2Purity：98%

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CAS No.	2409964-23-2	Cat. No.	BCP39659
Name	PXS5505 HCl
Synonyms	LOX-IN-3 dihydrochloride;PXS-5505 HCl;PXS 5505 HCl;
SMILES	C1=CC2=C(C(=C1)S(=O)(=O)CC(=CCN)F)N=CC=C2.Cl.Cl
Chemical Name
Formula	C13H15Cl2FN2O2S	M. Wt	353.23
Purity	98%	Storage	Store at 4-8°C
Description	LOX-IN-3 dihydrochloride is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 dihydrochloride can be used for fibrosis, cancer and angiogenesis research.PXS-5505 is a Pan-Lysyl Oxidase Inhibitor that has been found to ameliorate multiple-organ fibrosis by inhibiting collagen crosslinks in rodent models in systemic sclerosis. PXS-5505 inhibited lysyl oxidase activity in the skin and LOXL2 activity in the lung. PXS-5505 exhibited anti-fibrotic effects in the SSc skin mouse model, reducing dermal thickness and α-smooth muscle actin. Similarly, in the bleomycin-induced mouse lung model, PXS-5505 reduced pulmonary fibrosis toward normal levels, mediated by its ability to normalise collagen/elastin crosslink formation. PXS-5505 also reduced fibrotic extent in models of the ischaemia-reperfusion heart, the unilateral ureteral obstruction kidney, and the CCl4-induced fibrotic liver.