Larotrectinib sulfate New
Data Sheet
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| CAS No. | 1223405-08-0 | Cat. No. | BCP24096 |
| Name | Larotrectinib sulfate | ||
| Synonyms | LOXO 101 sulfate;LOXO101 sulfate;LOXO-101 sulfate; | ||
| SMILES | C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O | ||
| Chemical Name | |||
| Formula | C21H24F2N6O6S | M. Wt | 526.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Larotrectinib Sulfate is the sulfate salt form of larotrectinib, an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. | ||
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