ONO7475 New
Data Sheet
For research use only. Not for human use.
| Size | Price | Stock | Quotation Inquiry |
|---|---|---|---|
| 500.00 mg | Get quote | In-stock | Quotation Inquiry |
| 1.00 g | Get quote | In-stock | Quotation Inquiry |
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| CAS No. | 1646839-59-9 | Cat. No. | BCP33232 |
| Name | ONO7475 | ||
| Synonyms | ONO-7475; ONO 7475; | ||
| SMILES | O=C(C1=CC2=C(N(C3=CC=CC=C3)C1=O)CCCC2=O)NC4=NC=C(OC5=CC=NC6=CC(OC)=C(OC)C=C56)C=C4 | ||
| Chemical Name | |||
| Formula | C32H26N4O6 | M. Wt | 562.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ONO-7475 is a potent, selective, and orally active novel Anexelekto/MER tyrosine kinase inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC). | ||
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