NB-360 HCl New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1262855-97-9 | Cat. No. | BCP30332 |
| Name | NB-360 HCl | ||
| Synonyms | NB 360 HCl；NB360 HCl；NB-360 Hydrochloride; | ||
| SMILES | CC1=C(C(NC2=CC=C(F)C([C@]3(C)CO[C@@](C)(C(F)(F)F)C(N)=N3)=C2)=O)N=CC(C#N)=C1 | ||
| Chemical Name | |||
| Formula | C21H20ClF4N5O2 | M. Wt | 485.87 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared. | ||
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