Umibecestat HCl New
Data Sheet
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| CAS No. | 2365306-62-1 | Cat. No. | BCP48028 |
| Name | Umibecestat HCl | ||
| Synonyms | Umibecestat hydrochloride; | ||
| SMILES | CC1(COC(C(=N1)N)(C)C(F)(F)F)C2=C(C=CC(=N2)NC(=O)C3=C(C=C(C=N3)C(F)(F)F)Cl)F.Cl | ||
| Chemical Name | |||
| Formula | C19H16Cl2F7N5O2 | M. Wt | 550.26 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice. | ||
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