HG6-64-1
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1315329-43-1 | Cat. No. | BCP11080 |
| Name | HG6-64-1 | ||
| Synonyms | HG-6-64-1;HG 6-64-1; | ||
| SMILES | O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(/C=C/C4=CN=C(NC=C5)C5=C4OC)=C3 | ||
| Chemical Name | |||
| Formula | C32H34F3N5O2 | M. Wt | 577.64 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively; also inhibits ZAK, p38α, Src, Lyn, CSK and EPH-family kinases (IC50=50-100 nM); inhibits GCK signaling DLBCL cell lines with EC50 of 1.83-157 nM, induces G0/G1 cell-cycle arrest and cell death; inhibits the growth of DLBCL xenograft tumors and prolongs the survival of tumor-bearing mice. | ||
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