GNE-495 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1449277-10-4 | Cat. No. | BCP36075 |
| Name | GNE-495 | ||
| Synonyms | GNE 495; GNE495; | ||
| SMILES | C1CC1C(=O)N2CC(C2)NC(=O)C3=CN=C(C4=C3C=CC(=N4)C5=CC(=CC=C5)F)N | ||
| Chemical Name | |||
| Formula | C22H20FN5O2 | M. Wt | 405.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GNE-495 is a potent and selective MAP4K4 Inhibitor with efficacy in retinal angiogenesis. GNE-495 showed excellent potency and good PK and was used to demonstrate in vivo efficacy in a retinal angiogenesis model recapitulating effects that were observed in the inducible Map4k4 knockout mice. Mitogen-activated protein kinase kinase kinase kinase (MAP4K4, or HGK), and its homologues Misshapen and MIG-15 have been shown to regulate a multitude of biological processes, including embryonic development,metabolism, inflammation, neural regeneration, angiogenesis, and cancer. | ||
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