KPT-185
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1333151-73-7 | Cat. No. | BCP08195 |
| Name | KPT-185 | ||
| Synonyms | KPT185;KPT 185; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H16F3N3O3 | M. Wt | 355.31 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts. KPT-185 reduces CRM1 protein protein level and shows a significant nuclear accumulation of CRM1 cargo proteins. KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells. | ||
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