Selinexor New
Data Sheet
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| CAS No. | 1393477-72-9 | Cat. No. | BCP08966 |
| Name | Selinexor | ||
| Synonyms | 1421923-86-5(E-isomer) ;KPT-330;KPT 330;KPT330; Xpovio; | ||
| SMILES | C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F | ||
| Chemical Name | |||
| Formula | C17H11F6N7O | M. Wt | 443.31 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | KPT-330 dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–11) in vivo, with little toxicity to normal haematopoietic cells. In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330 directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and NFATc1, with minimal impact on osteoblasts and BMSCs. | ||
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