Taminadenant New
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| CAS No. | 1337962-47-6 | Cat. No. | BCP48237 |
| Name | Taminadenant | ||
| Synonyms | PBF-509; PBF 509; PBF509; NIR-178; NIR 178; NIR178; | ||
| SMILES | C1=CN(N=C1)C2=NC(=NC(=C2Br)N)N3C=CC=N3 | ||
| Chemical Name | |||
| Formula | C10H8BrN7 | M. Wt | 306.12 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells. | ||
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