Runcaciguat New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP42634CAS No. ：1402936-61-1Purity：98%

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CAS No.	1402936-61-1	Cat. No.	BCP42634
Name	Runcaciguat
Synonyms	BAY 1101042; BAY-1101042 BAY1101042;
SMILES	CC(C(C1=CC=C(C=C1)Cl)C(=O)NC2=C(C=CC(=C2)C(CC(=O)O)C3CC3)Cl)C(F)(F)F
Chemical Name
Formula	C23H23Cl2F3NO3	M. Wt	489.33
Purity	98%	Storage	Store at 4-8°C
Description	Runcaciguat is a novel, potent, and orally active sGC activator. Runcaciguat activated the sGC reporter cell line with an EC50 value of 11.2 ± 1.0 nM. Pretreatment of the sGC reporter cell line with 30 μM ODQ for 3 h resulted in an increased potency of runcaciguat (EC50 of 2.1 ± 0.07 nM), and treatment of the reporter cells with runcaciguat in combination with the NO donor S-nitroso-N-acetylpenicillamine (SNAP) (10 and 100 nM) showed additive effects. Treatment with runcaciguat resulted in maximal luminescence signals in the range of 50–60% in comparison to the sGC activator cinaciguat. Given the broad impact of oxidative stress in cardiovascular and cardiorenal diseases, runcaciguat might become a new treatment modality for a broad variety of diseases in these indication space but also beyond.