Derenofylline New
Data Sheet
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| CAS No. | 251945-92-3 | Cat. No. | BCP32768 |
| Name | Derenofylline | ||
| Synonyms | SLV-320; SLV 320; SLV 320; | ||
| SMILES | C1CC(CCC1NC2=NC(=NC3=C2C=CN3)C4=CC=CC=C4)O | ||
| Chemical Name | |||
| Formula | C18H20N4O | M. Wt | 308.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Derenofylline, also known as SLV320, is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM) with a selectivity factor of at least 200 versus other adenosine receptor subtypes. SLV320 significantly decreased albuminuria by about 50%, but did not alter glomerular filtration rate (GFR). SLV320 prevented nephrectomy-dependent rise in plasma levels of creatinine kinase (CK), ALT and AST. SLV320 suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats with 5/6 nephrectomy. | ||
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