(S)-(-)-PH-797804 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1358027-80-1 | Cat. No. | BCP49370 |
| Name | (S)-(-)-PH-797804 | ||
| Synonyms | PH 797804;PH-797804;PH797804; | ||
| SMILES | CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C | ||
| Chemical Name | |||
| Formula | C22H19BrF2N2O3 | M. Wt | 477.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PH 797804 is a potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active. | ||
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