M2698
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1379545-95-5 | Cat. No. | BCP19488 |
| Name | M2698 | ||
| Synonyms | M-2698;M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A; | ||
| SMILES | O=C(C1=CC=CC2=C(N[C@@H](C3=CC=C(Cl)C(C(F)(F)F)=C3)CN4CCC4)N=CN=C12)N | ||
| Chemical Name | |||
| Formula | C21H19ClF3N5O | M. Wt | 449.86 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | M2698, also known as MSC-2363318A, is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. M2698 was highly potent in vitro (IC50 1 nM for p70S6K, Akt1 and Akt3 inhibition; IC50 17 nM for pGSK3β indirect inhibition) and in vivo (IC50 15 nM for pS6 indirect inhibition), and relatively selective (only 6/264 kinases had an IC50 within 10-fold of p70S6K). | ||
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