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PIT 1 Chemical Structure

PIT 1

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP27689CAS No. ：53501-41-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 53501-41-0 Cat. No. BCP27689
Name PIT 1
Synonyms PIT-1;PIT1;
SMILES C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC(=CC(=C2O)Cl)[N+](=O)[O-]
Chemical Name
Formula C14H10ClN3O4S M. Wt 351.76
Purity 98% Storage Store at 4-8°C
Description PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM. PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM).
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