(E)-Akt inhibitor-IV New
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 959841-49-7 | Cat. No. | BCP46776 |
| Related Products | 681281-88-9（Akt Inhibitor IV） | ||
| Name | (E)-Akt inhibitor-IV | ||
| Synonyms | AKTIV; AKT Inhibitor-IV; AKT Inhibitor IV;(E)-AKTIV; | ||
| SMILES | CCN1C(N(C2=C1C=C(C=C2)C3=NC4=CC=CC=C4S3)C5=CC=CC=C5)C=CN(C)C6=CC=CC=C6.I | ||
| Chemical Name | |||
| Formula | C31H27IN4S | M. Wt | 614.55 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AKT Inhibitor IV promotes hyperphosphorylation of Akt (Protein kinase B), decreases phosphorylation of Akt substrates, and inhibits FOXO1a nuclear export (IC50 = 625 nM in PTEN-null cells). AKT Inhibitor IV inhibits the proliferation of several cells lines (IC50 values are <1.25 μM, 320 - 670 nM and 340 nM for 786-O, HeLa and Jurkat cells, respectively). This compound also displays broad antiviral activity against negative-stranded RNA viruses; inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC50 = 520 nM). In HeLa cells, AKT Inhibitor IV accumulates in mitochondria, disrupting morphology and increasing ROS production. At high concentrations (10 μM), AKT Inhibitor IV activates the unfolded protein response and apoptosis in HEK293T cells. AKT Inhibitor IV is weakly fluorescent upon irradiation with UV light (excitation/emission maxima λ ~ 388/460; quantum yield = 0.0016). | ||
Recommend Products
More >
-
Solenopsin HCl
Cat. No.：BCP49141
No.：137119-46-1
Product Details -
Solenopsin
Cat. No.：BCP48761
No.：137038-57-4
Product Details -
ONC-201 Dihydrochloride
Cat. No.：BCP46830
No.：1638178-82-1
Product Details -
A674563 HCl
Cat. No.：BCP46680
No.：A674563HCl
Product Details -
Borussertib
Cat. No.：BCP43065
No.：1800070-77-2
Product Details -
-
Merck-22-6
Cat. No.：BCP36078
No.：612847-42-4
Product Details -
-
Recilisib sodium
Cat. No.：BCP35048
No.：922139-31-9
Product Details -
E-Guggulsterone
Cat. No.：BCP34834
No.：39025-24-6
Product Details -
-
AT7867 dihydrochloride
Cat. No.：BCP30936
No.：1431697-86-7
Product Details -
-
Miransertib HCl
Cat. No.：BCP25709
No.：1313883-00-9
Product Details -
-
-
Ipatasertib dihydrochloride
Cat. No.：BCP23821
No.：1396257-94-5
Product Details -
-
Akt Inhibitor IV
Cat. No.：BCP22722
No.：681281-88-9
Product Details -
(Z)-Guggulsterone
Cat. No.：BCP07472
No.：39025-23-5
Product Details
Tags:(E)-Akt inhibitor-IV supplier,(E)-Akt inhibitor-IV purchase,(E)-Akt inhibitor-IV manufacturer,(E)-Akt inhibitor-IV distributor,(E)-Akt inhibitor-IV cost,(E)-Akt inhibitor-IV buy,(E)-Akt inhibitor-IV for sale