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Vodobatinib Chemical Structure

Vodobatinib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP43522CAS No. :1388803-90-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1388803-90-4 Cat. No. BCP43522
Name Vodobatinib
Synonyms K-0706; K0706; K0706;
SMILES CC1=C(C(=CC=C1)Cl)C(=O)NNC(=O)C2=CC(=C(C=C2)C)C#CC3=CC4=CC=CC=C4N=C3
Chemical Name
Formula C27H20ClN3O2 M. Wt 453.92
Purity 98% Storage Store at 4-8°C
Description Vodobatinib is an orally bioavailable, Bcr-Abl tyrosine kinase inhibitor (TKI), with potential antineoplastic activity. Upon administration, vodobatinib selectively targets and binds to the Bcr-Abl fusion oncoprotein, including various Bcr-Abl mutant forms, such as those with the 'gatekeeper' resistance mutation T315I. This inhibits proliferation of Bcr-Abl-expressing tumor cells. The Bcr-Abl fusion protein is an aberrantly activated tyrosine kinase produced by certain leukemia cells. T315I, an amino acid substitution where threonine (T) has been mutated to isoleucine (I) at position 315 in the tyrosine-protein kinase ABL1 portion of the Bcr-Abl fusion protein, plays a key role in resistance to certain chemotherapeutic agents and its expression is associated with poor prognosis.
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