Empesertib New
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| CAS No. | 1443763-60-7 | Cat. No. | BCP23811 |
| Name | Empesertib | ||
| Synonyms | BAY1161909; BAY-1161909; BAY 1161909;Mps1-IN-5; | ||
| SMILES | FC1=CC=C([C@@H](C)C(NC2=CC=C(C3=CN4N=C(NC5=CC=C(S(C)(=O)=O)C=C5OC)N=C4C=C3)C=C2)=O)C=C1 | ||
| Chemical Name | |||
| Formula | C29H26FN5O4 | M. Wt | 559.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Empesertib, also known as BAY1161909, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase, with potential antineoplastic activity. Upon administration, the Mps1 kinase inhibitor BAY1161909 binds to and inhibits the activity of Mps1. This causes inactivation of the spindle assembly checkpoint (SAC), accelerated mitosis, chromosomal misalignment, chromosomal missegregation, mitotic checkpoint complex destabilization, and increased aneuploidy. This leads to the induction of cell death in cancer cells overexpressing Mps1. | ||
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