CFI-402257 New
Data Sheet
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| CAS No. | 1610759-22-2 | Cat. No. | BCP31204 |
| Name | CFI-402257 | ||
| Synonyms | CFI 402257; CFI402257; | ||
| SMILES | CC1=C(C=CC(=C1)C2=C3N=C(C=C(N3N=C2)NCC4CC(C4)(C)O)OC5=CN=CC=C5)C(=O)NC6CC6 | ||
| Chemical Name | |||
| Formula | C28H30N6O3 | M. Wt | 498.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CFI-402257 is a highly potent and selective TTK (threonine tyrosine kinase) Inhibitor ((TTK Ki = 0.1 nM) with potential anticancer activity. TTK is an essential chromosomal regulator and is overexpressed in aneuploid tumors. High TTK levels correlate with a high tumor grade11 and poor patient outcomes. TTK inhibition are associated with a disabled mitotic checkpoint, resulting in chromosome segregation errors, aneuploidy, and cell death. | ||
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