MPS1-IN-3 New
Data Sheet
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| CAS No. | 1609584-72-6 | Cat. No. | BCP37980 |
| Name | MPS1-IN-3 | ||
| Synonyms | Mps1 IN3; Mps1-IN3; | ||
| SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC3=C2NC=N3)NC4=C(C=C(C=C4)N5CCC(CC5)O)OC | ||
| Chemical Name | |||
| Formula | C26H31N7O4S | M. Wt | 537.64 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MPS1-IN-3 is a selective and potent MPS1 inhibitor with phenotypic consequences similar to those reported for published MPS1 inhibitors such as MPS1-IN-1, MPS1-IN-2, and AZD3146. MPS1-IN-3 sensitizes glioblastoma cells to vincristine both in vitro and in murine tumor models. MPS1 may be a promising therapeutic target for high-grade glioma therapy and that MPS1 inhibition by MPS1-IN-3 efficiently sensitizes glioblastoma cells to antimitotic agents. | ||
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