K145 hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1449240-68-9 | Cat. No. | BCP43089 |
| Name | K145 hydrochloride | ||
| Synonyms | K145 HCl; K 145 HCl; K-145 HCl; K-145 hydrochloride; | ||
| SMILES | CCCCOC1=CC=C(C=C1)CCC=C2C(=O)N(C(=O)S2)CCN.Cl | ||
| Chemical Name | |||
| Formula | C18H25ClN2O3S | M. Wt | 384.92 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30±0.06 µM. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti-tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model. | ||
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