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CAS No. | 896657-58-2 | Cat. No. | BCP49045 |
Name | MGH-CP1 | ||
Synonyms | MGHCP1; MGH CP1; | ||
SMILES | C1C2CC3CC1CC(C2)(C3)C4=CC=C(C=C4)NC(=O)CSC5=NC=NN5 | ||
Chemical Name | |||
Formula | C20H24N4OS | M. Wt | 368.49 |
Purity | 98% | Storage | Store at 4-8°C |
Description | MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC50s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion. |
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