(5Z,2E)-CU-3 New
Data Sheet
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| CAS No. | 1815598-71-0 | Cat. No. | BCP45169 |
| Name | (5Z,2E)-CU-3 | ||
| Synonyms | DGKα inhibitor CU-3; | ||
| SMILES | C1=CC=C(C=C1)S(=O)(=O)NN2C(=O)C(=CC=CC3=CC=CO3)SC2=S | ||
| Chemical Name | |||
| Formula | C16H12N2O4S3 | M. Wt | 392.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells. | ||
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