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L-733060 hydrochloride Chemical Structure

L-733060 hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP49092CAS No. :148687-76-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 148687-76-7 Cat. No. BCP49092
Name L-733060 hydrochloride
Synonyms L-733,060; L733,060; L 733,060; L-733060; L733060; L 733060; L-733060 HCl salt;
SMILES C1CC(C(NC1)C2=CC=CC=C2)OCC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F.Cl
Chemical Name
Formula C20H20ClF6NO M. Wt 439.82
Purity 98% Storage Store at 4-8°C
Description L-733,060 is an orally active, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine. It shows antiinflammatory and anti-hepatotoxic effects in animals, and counteracts the development of hyperalgesia following nerve injury.[15][16] It also has anticancer effects in a variety of in vitro models.
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