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CAS No. | 1628287-16-0 | Cat. No. | BCP35558 |
Name | Pico145 | ||
Synonyms | Pico-145; Pico 145; HC-608; HC 608; HC608; | ||
SMILES | ClC1=CC=C(CN2C(C(N(C3=O)CCCO)=O)=C(N=C2OC4=CC=CC(OC(F)(F)F)=C4)N3C)C=C1 | ||
Chemical Name | |||
Formula | C23H20ClF3N4O5 | M. Wt | 524.88 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8. |
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