CCG-222740 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1922098-69-8 | Cat. No. | BCP31985 |
| Name | CCG-222740 | ||
| Synonyms | CCG 222740; CCG222740; | ||
| SMILES | C1C(CN(CC1(F)F)C(=O)C2=CC=CC(=C2)C3=CC=CO3)C(=O)NC4=CC=C(C=C4)Cl | ||
| Chemical Name | |||
| Formula | C23H19ClF2N2O3 | M. Wt | 444.86 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CCG-222740 is a potent MRTF/SRF inhibitor. CCG-222740 markedly decreased SRF reporter gene activity and showed a greater inhibitory effect on MRTF/SRF target genes than the previously described MRTF-A inhibitor CCG-203971. CCG-222740 was also five times more potent, with an IC50 of 5 μM, in a fibroblast-mediated collagen contraction assay, was less cytotoxic, and a more potent inhibitor of alpha-smooth muscle actin protein expression than CCG-203971. | ||
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