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Milademetan tosylate monohydrate Chemical Structure

Milademetan tosylate monohydrate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP31919CAS No. :2095625-97-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2095625-97-9 Cat. No. BCP31919
Name Milademetan tosylate monohydrate
Synonyms DS3032b; DS-3032b; DS 3032b; DS3032; DS-3032; DS 3032;
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC1(CCC2(CC1)C3(C(C(N2)C(=O)NC4CCC(OC4)C(=O)N)C5=C(C(=NC=C5)Cl)F)C6=C(C=C(C=C6)Cl)NC3=O)C.O
Chemical Name
Formula C37H44Cl2FN5O8S M. Wt 808.74
Purity 98% Storage Store at 4-8°C
Description Milademetan, also known as DS-3032b, is a potent and selective MDM2 inhibitor with potential antineoplastic activity. Upon oral administration, MDM2 inhibitor DS-3032b binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.
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