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RG7112 Chemical Structure

RG7112

Data Sheet For research use only. Not for human use.
Cat. No. :BCP07937CAS No. :939981-39-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 939981-39-2 Cat. No. BCP07937
Name RG7112
Synonyms RG-7112;RG 7112; RO-5045337; RO 5045337; RO5045337;
SMILES C[C@@]1([C@](C)(N(C(C2=CC=C(C=C2OCC)C(C)(C)C)=N1)C(N3CCN(CC3)CCCS(=O)(C)=O)=O)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Chemical Name
Formula C38H48Cl2N4O4S M. Wt 727.78
Purity 98% Storage Store at 4-8°C
Description RO5045337, also known as RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.
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