Nutlin-3b
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CAS No. | 675576-97-3 | Cat. No. | BCP05162 |
Name | Nutlin-3b | ||
Synonyms | Nutlin 3b;Nutlin3b; | ||
SMILES | |||
Chemical Name | |||
Formula | C30H30Cl2N4O4 | M. Wt | 581.49 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Nutlin-3b is useful as a negative control s for non-MDM2-related cellular activities. Nutlin-3a induces the expression of MDM2 and p21 (but not p53) only in cells with wild-type p53. Nutlin-3b has no effect regardless of the p53 status of the cells. Only the active enantiomer Nutlin-3a shows a potent antiproliferative activity and clear separation of potency between the cells harboring wild-type p53 and those harboring mutant p53. The potency of Nutlin-3b is much lower in the wild-type p53 cells and nearly identical to the potency of Nutlin-3a against the mutant p53 cells. After 48 hours of exposure to the Nutlin-3a, 45% of the cell population became TUNEL positive, but cells treated with the Nutlin-3b are indistinguishable from the untreated controls. |
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