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Nutlin-3b Chemical Structure

Nutlin-3b

Data Sheet For research use only. Not for human use.
Cat. No. :BCP05162CAS No. :675576-97-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 675576-97-3 Cat. No. BCP05162
Name Nutlin-3b
Synonyms Nutlin 3b;Nutlin3b;
SMILES
Chemical Name
Formula C30H30Cl2N4O4 M. Wt 581.49
Purity 98% Storage Store at 4-8°C
Description Nutlin-3b is useful as a negative control s for non-MDM2-related cellular activities. Nutlin-3a induces the expression of MDM2 and p21 (but not p53) only in cells with wild-type p53. Nutlin-3b has no effect regardless of the p53 status of the cells. Only the active enantiomer Nutlin-3a shows a potent antiproliferative activity and clear separation of potency between the cells harboring wild-type p53 and those harboring mutant p53. The potency of Nutlin-3b is much lower in the wild-type p53 cells and nearly identical to the potency of Nutlin-3a against the mutant p53 cells. After 48 hours of exposure to the Nutlin-3a, 45% of the cell population became TUNEL positive, but cells treated with the Nutlin-3b are indistinguishable from the untreated controls.
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