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Lu AF27139 Chemical Structure

Lu AF27139

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP44190CAS No. ：2097117-06-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 2097117-06-9 Cat. No. BCP44190
Name Lu AF27139
Synonyms LuAF27139; Lu-AF27139;
SMILES ClC1=CC=C([C@H](N2CCOCC2)CN([H])C(C3=C(C(F)(F)F)N=C(C4=NC=CC=N4)S3)=O)C=C1
Chemical Name
Formula C21H19ClF3N5O2S M. Wt 497.92
Purity 98% Storage Store at 4-8°C
Description Lu AF27139 is a novel rodent-active and CNS penetrant P2X7 receptor antagonist. Lu AF27139 is highly selective and potent against rat, mouse, and human forms of the receptors. The rat pharmacokinetic profile is favorable with high oral bioavailability, modest clearance (0.79 L/(h kg)), and good CNS permeability. Lu AF27139 will be a valuable tool for probing the role of the P2X7 receptor in rodent models of CNS diseases.
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