ONT093
Data Sheet
For research use only. Not for human use.
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| CAS No. | 216227-54-2 | Cat. No. | BCP24637 |
| Name | ONT093 | ||
| Synonyms | ONT-093; ONT 093; OC-144-093; OC 144-093; OC144-093; OC-144093; OC 144093; OC144093; Benzenamine; | ||
| SMILES | CC(C)NC1=CC=C(C2=C(C3=CC=C(NC(C)C)C=C3)N=C(C4=CC=C(/C=C/COCC)C=C4)N2)C=C1 | ||
| Chemical Name | |||
| Formula | C32H38N4O | M. Wt | 494.67 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ONT-093, also known as OC-144-093, is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics. OC144-093 is the least non-specifically toxic Pgp inhibitor described to date, with an average cytostatic IC50 of >60 microM in 15 cell types. OC144-093 may represent an ideal candidate for use in enhancement of AED blood-brain barrier penetration. | ||
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