Genz-123346
Data Sheet
For research use only. Not for human use.
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| CAS No. | 491833-30-8 | Cat. No. | BCP11811 |
| Name | Genz-123346 | ||
| Synonyms | Genz123346;Genz 123346; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H38N2O4 | M. Wt | 418.57 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function. | ||
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