NH125
Data Sheet
For research use only. Not for human use.
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| CAS No. | 278603-08-0 | Cat. No. | BCP29662 |
| Name | NH125 | ||
| Synonyms | NH-125; NH 125;eEF-2 Kinase Inhibitor, NH125; | ||
| SMILES | CCCCCCCCCCCCCCCCN1C=C[N+](=C1C)CC2=CC=CC=C2.[I-] | ||
| Chemical Name | |||
| Formula | C27H45N2.I | M. Wt | 524.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NH125 is a Eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC50 values are 0.7 - 4.8 μM) and blocks G1/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro (IC50 = 6.6 μM) and in vivo. | ||
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