Sarizotan New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP24751CAS No. ：351862-32-3Purity：98%

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CAS No.	351862-32-3	Cat. No.	BCP24751
Name	Sarizotan
Synonyms	EMD-128130; EMD128130; EMD 128130; EMD-77697; EMD-77697; EMD-77697;
SMILES	C1CC2=CC=CC=C2OC1CNCC3=CC(=CN=C3)C4=CC=C(C=C4)F
Chemical Name
Formula	C22H21FN2O	M. Wt	348.41
Purity	98%	Storage	Store at 4-8°C
Description	Sarizotan is a Dopamine D2 receptor partial agonist and Serotonin 1A receptor agonist. Sarizotan exhibits affinity at serotonin and dopamine receptors. Sarizotan effectively suppresses levodopa-induced dyskinesia in primate and rodent models of Parkinson's disease, and tardive dyskinesia in a rodent model. Sarizotan is a full agonist at D3 and D4.4 receptors (EC50=5.6 and 5.4 nM, respectively) but a partial agonist at D2S, D2L and D4.2 receptors (EC50=29, 23 and 4.5 nM, respectively). Sarizotan is an antagonist at D2S and D2L receptors (IC50=52 and 121 nM, respectively). Sarizotan is a full agonist at D2L, D3, D4.2 and D4.4 receptors (EC50=0.51, 0.47, 0.48 and 0.23 nM, respectively) but a partial agonist at D2S receptors (EC50=0.6 nM).