LY518674 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 425671-29-0 | Cat. No. | BCP34904 |
| Name | LY518674 | ||
| Synonyms | LY-518674; LY 518674;LY-674;LY 674;LY674; | ||
| SMILES | CC1=CC=C(C=C1)CN2C(=O)NC(=N2)CCCC3=CC=C(C=C3)OC(C)(C)C(=O)O | ||
| Chemical Name | |||
| Formula | C23H27N3O4 | M. Wt | 409.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LY518674 is a Potent and selective PPAR-alpha agonist. LY518674 upregulates both ApoA-I production and catabolism in human subjects with the metabolic syndrome. LY518674 produced a dose-dependent increase in serum HDL-c, resulting in 208 +/- 15% elevation at optimum dose. In cultured hepatocytes, LY518674 produced 50% higher apoA-1 secretion, which was associated with increase in radiolabeled methionine incorporation in apoA-1. LY518674 is a potent and selective PPARalpha agonist that produced a much greater increase in serum HDL-c than the known fibrate drugs. | ||
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