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Kartogenin Chemical Structure

Kartogenin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP09135CAS No. :4727-31-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 4727-31-5 Cat. No. BCP09135
Name Kartogenin
Synonyms KGN; 2-([1,1'-Biphenyl]-4-ylcarbamoyl)benzoic acid; 2-[(4-phenylphenyl)carbamoyl]benzoic acid;4'-Phenylphthalanilic Acid;
SMILES
Chemical Name
Formula C20H15NO3 M. Wt 317.34
Purity 98% Storage Store at 4-8°C
Description Kartogenin is a small molecule kartogenin, which promotes chondrocyte differentiation (median effective concentration = 100 nM), shows chondroprotective effects in vitro, and is efficacious in two OA animal models. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program . KGN stimulated type-I collagen synthesis of fibroblasts at the mRNA and protein levels in a time-dependent manner, but KGN did not induce expression of α-skeletal muscle actin (α-sma) or matrix metallopeptidase1 (MMP1), MMP9 in vitro . KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4/smad5 pathway.
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